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Inflammation and increased oxidative stress related to NASH accelerate liver cell damage and trigger fibrotic processes that can progress to cirrhosis and liver failure, a terminal condition treatable only with liver transplant

A pooled analysis published in the National Institutes of Health PMC archive found tirzepatide reduced body weight more than semaglutide across different study designs, and a journal review summarized by the American College of Cardiology reported significantly greater weight loss with tirzepatide

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Since efferocytosis is a crucial function of pro-resolving macrophages, we then compared the ability of these polarized populations to clear apoptotic cells