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Biochimie 91 , 12731277 (2009)

At a genome-wide significant level, three loci (ABCG2, SLC2A9, and CUX2) have been identified in association with renal urate overload, whereas four loci (ABCG2, SLC2A9, CUX2, and GCKR) have been linked to renal urate underexcretion

3) Isolated mitochondrial respiration was reduced in DM and DM_CKD hearts across multiple substrates (fatty acids, pyruvate-malate, glutamate-malate, and succinate), implicating broad mitochondrial dysfunction

Compared with adult-derived MSCs, fetal-derived MSCs secrete EVs containing more proteins and possess stronger functional characteristics, including migration, cell development, and metabolic processes [60]