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Given its proximity to helices 10 and 11 of the HECT N-lobe and to the binding interface between the HECT and C2 domains, the catalytic residue C922 cannot be accessed in Nedd4-2 (Fig

Due to the formation of an -helical turn in the loop connecting 4 to 6 of monomer A, Arg122 rotates away from Glu48 and engages in a salt-bridge interaction with the O1 and O3 of the triple oxidized Cys45

On the other hand, cellular GPx activity level showed a positive correlation with quasi-threshold doses (Dq) and extrapolation numbers but not with general radiosensitivity

Epigenetic modifications are reversible and potentially heritable alterations in gene expression that occur independently of changes in the DNA sequence