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These studies found structural and functional defects in the 26S and 20S proteasomes, with a significant loss of the alpha subunit of the 20S proteasome, a loss of its enzymatic activity, and a significant decrease in the regulatory function of the 19S particles [128, 134, 135]

This paper draws attention to the extracellular matrix composition of demyelinated lesions as an important determinant of remyelination efficiency and how remyelination can be improved by pharmacological manipulation of the lesion extracellular matrix

In the condition known as functional hypothyroidism, the thyroid hormones cannot control metabolism efficiently because of the excessive synthesis of rT3 and the lack of T3

Human IL10 gene repression by Rev-erb ameliorates Mycobacterium tuberculosis clearance