dihexa synaptic plasticity Abnormal and impaired cognition in schizophrenia Dihexa (also known as PNB-0408)

Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted Frontiers Synaptic Plasticity in Cortical Inhibitory Neurons: What Mechanisms May Help to Balance Synaptic Weight Changes? Control of synaptic plasticity in deep cortical networks Nature Reviews Neuroscience From Synaptic Plasticity to Neurodegeneration: BDNF as a Transformative Target in Medicine

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