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This state is accompanied by diet-dependent remodeling of the host small intestinal microbiota and metabolome: whereas fiber-rich diets support fermentative microbial communities and a chemically diverse intestinal environment, the Western diet promotes dysbiotic profiles with reduced fermentation capacity and a more pro-inflammatory immune response

HDL-NPs downregulated GPX4 mRNA expression, thereby directly inducing ferroptosis, although the underlying mechanisms remain unknown 132

Tannins significantly reduced the phase I and phase II enzyme activities in mouse liver tissues ( Salvianolic acid B, a rosmarinic acid dimer, is an active component of Salvia miltiorrhiza Bunge [Lamiaceae], and its reduction of drug-induced liver injury is associated with its antioxidant activity ( Chlorogenic acid, a phenolic compound with various biological activities, ameliorates liver injury in an experimentally induced model of oxidative stress ( Caffeic acid is a common phenolic chemical found in a wide variety of plants

Ca 2+ then enters the mitochondrial matrix through the mitochondrial calcium uniporter (MCU) via the inner mitochondrial membrane (IMM)