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Localized delivery of carbon monoxide

More recently, this diet has gained popularity as an intervention for neurological disorders like Alzheimers and Parkinsons diseases for its ability to serve as an alternative fuel source for brain metabolism, reduce pro-inflammatory responses and oxidative stress, and improve mitochondrial function and biogenesis (Pietrzak et al., 2022)

Data from human genetic disorders, mouse models and in vitro studies is discussed to illustrate how disruption of PUFA pathways in the RPE leads to lipid imbalance and retinal degeneration, and to highlight how these findings illuminate molecular mechanisms underlying PUFA biology

doi: 10.1016/j.immuni.2013.10.022 47 WuHWSheardMAMalvarJFernandezGEDeClerckYABlavierLet al