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This upregulation leads to an increased expression of lipogenic genes, including sterol regulatory element-binding proteins (SREBP1c) and diacylglycerol acyltransferase-2 (DGAT2), which suggests that miR-370 provides a further point of regulation of this pathway 86

Finally human clinical studies that measure TMAO, track cardiovascular endpoints, and examine microbiome interactions with L-carnitine will better define clinical relevance