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Mild deficiency: Patients with mild B12 deficiency might only need a small dose

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The JNK and NF-B signaling pathways have been involved in the regulation of the macrophage phenotype, and their phosphorylation can induce macrophage M1 polarization

Dosing information Usual Adult Dose for Pernicious Anemia: Initial dose: 100 mcg intramuscularly or deep subcutaneous once a day for 6 to 7 days If clinical improvement and reticulocyte response is seen from the above dosing: 100 mcg every other day for 7 doses, then: 100 mcg every 3 to 4 days for 2 to 3 weeks, then: Maintenance dose: 100 to 1000 mcg monthly Duration of therapy: Life Comments: Administer concomitant folic acid if needed