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This necessitates a fundamental shift towards a proactive safe-and-sustainable-by-design (SSbD) framework, where considerations of ecological safety and lifecycle sustainability are not an afterthought, but are integral components of the material innovation process from its inception.185,186 The SSbD framework defined by the European Commissions Joint Research Centre (JRC) 2023 report, which integrates safety assessment into the earliest stages of innovation, is advocated