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Testicular function and fertility outcomes in males with CF: a multi center retrospective study of men with congenital bilateral absence of the vas deferens based on CFTR mutation status

6 This observation marked the initial recognition of mitochondrial functional alterations in cancer metabolism and sparked early investigations into the role of organelles in tumorigenesis

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One way to test for these types of effects is to compare a chronic gene deficiency with acute knockdown experiments and if the results are different, adaptive responses likely impacted the injury mechanism [153]