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Collectively, these results demonstrate that DLBCL cells, regardless of subtype, exhibit profound sensitivity to ferroptosis induction via small molecule GPX4 inhibition, and that this vulnerability is specific to malignant B-cells, supporting ferroptosis as a selective and mechanistically distinct strategy for therapeutic intervention in aggressive lymphomas

ROS originate from electron dissipation that occurs when ATP is synthesized coupled to O 2 reduction by ATP synthase

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ESC prevented hepatocyte apoptosis by reducing the Bcl-2-to-BAX ratio and inhibiting caspase-3 activation