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Chemical activity of V-B12 Metabolic effects Cobalamins are essential in two main cellular reactions: i) connecting lipid and carbohydrate metabolism via the mitochondrial methylmalonyl-CoA mutase conversion of methylmalonic acid to succinate, and ii) activating methionine synthase (synthesizes methionine from homocysteine and 5-methyltetrahydrofolate).43 As such, they are required for both heme and DNA synthesis

As a brief aside, readers may note that blood levels are not uniformly level at steady state

One study showed that depleted glutathione could then lead to depleted methionine

Among them, Vitamin B12 takes center stage as a critical player in our overall health and vitality