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Other symptoms are severe jaundice, diarrhoea, fever, pruritus, and hepatosplenomegaly

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[52] In light of the disappointing results of clinical trials involving the administration of so-called direct antioxidants (e.g., vitamins C or E or beta carotene) [37], there is growing interest in strategies based on dietary or pharmacological upregulation of endogenous antioxidant defense genes, including those regulated by the master antioxidant and cell protective transcription factor nuclear factor (erythroid-derived 2)-like-2 (Nrf2), which regulates hundreds of antioxidant and cytoprotective proteins [20] by binding at antioxidant response element (ARE) consensus sequences in the promoter region of those genes

Ovarian damages produced by aerosolized fine particulate matter (PM 2.5 ) pollution in mice: possible protective medications and mechanisms