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The specific mechanism may involve adipocyte-derived lactate enhancing ATM polarization into inflammatory subsets by binding competitively to the PHD2 catalytic domain in macrophages, stabilizing HIF-1 expression, and augmenting IL-1 production

36:e22107

In addition, hypermethylation of the p16 gene promoter contributes to inactivation of the p16 tumor suppressor gene, which is implicated in the progression from Barretts esophagus to esophageal adenocarcinoma