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doi: 10.3389/fpls.2023.1146577 62 HuangQ.ZhangM.LiC.LiB.ZhuoS.YangY.et al

It binds to toxins and neutralizes free radicals, enhances liver and kidney detox pathways, and supports cellular repair

Unmet needs include partial response and non-response to treatment in many patients, failure to achieve immune homeostasis or drug-free remission, and inability to repair damaged tissues

TDP-43 binds directly and with high affinity to m1A in RNA, which promotes the cytoplasmic mis-localization and subsequent formation of gel-like aggregates (Sun et al., 2023)