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Phenotypic drug discovery: Recent successes, lessons learned and new directions

As aforementioned, DMT1 and TfR1 are essential proteins found in cells that help regulate intracellular iron concentration, thereby serving a vital role in iron homeostasis

Although biochemically separated from the GSH system, the Trx system shares NADPH as a common reducing cofactor and serves as an alternative pathway for reducing disulfide bonds, making this system especially relevant if the GSH system has been compromised or rendered dysfunctional (Silva-Adaya et al., 2014)