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Because a major physiologic function of GSH is to provide cells with a reducing environment and to destroy the reactive oxygen compounds and free radicals formed in metabolism, organs that have low concentrations of other antioxidants (such as catalase and superoxide dismutase) are thought to be more dependent on GSH for detoxification of reactive oxygen species than are organs that have alternative antioxidants

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Furthermore, SGLT2 inhibition significantly decreased both MCP-1 and TNF- in the presence of an inflammatory stimulus such as LPS, suggesting the potential anti-inflammatory effects of SGLT2 inhibitors [123]

Early treatment is key to avoiding long-term pain and weakness