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Physical Medicine and Rehabilitation

Oxidative stress is involved in the mechanism of aging

Proc Natl Acad Sci USA 89 : 1019310197

Our results suggest that CBS of the TSS pathway plays an important role in maintaining cysteine levels under restricted cystine availability or excess hemin exposure, and CBS upregulation by DMF increases the cellular glutathione levels to protect against ROS and ferroptosis stress in SCD