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Nuclear Signaling : Glutathione levels influence the activation of Nrf2, a transcription factor that upregulates longevity pathways and antioxidant enzyme production, creating a supportive cellular environment against stress

To date, there are barely known published studies indicating that GPX4 expression is directly controlled by EBV lytic genes

Abbreviations AD: Alzheimers disease APP/PS1: Amyloid precursor protein/presenilin 1 A: -amyloid BDNF: Brain-derived neurotrophic factor CNS: Central nervous system CSF: Cerebrospinal fluid DAMPs: Danger-associated molecular patterns GDNF: Glial cell-derived neurotrophic factor ICAM-1: Intercellular cell adhesion molecular-1 IL-2: Interleukin 2 MT1: Melatonin receptor 1 MT2: Melatonin receptor 2 NFTs: Intracellular neurofibrillary tangles NF-B: Nuclear factor kappa B NSCs: Neural stem cells PAMPs: Pathogen-associated molecular patterns PECAM-1: Platelet endothelial cell adhesion molecular-1 REM: Rapid eye movements SCN: Suprachiasmatic nucleus SGZ: Subgranular zone SVZ: Sub-ventricular zone TLRs: Toll like receptor References Jack CR Jr, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, Petersen RC, Trojanowski JQ

& Cappello, F