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After a single hydroxocobalamin injection, therapeutic levels can be maintained for approximately 8 to 12 weeks in most patients, which aligns with the standard maintenance schedule of injections every 2-3 months recommended in the British National Formulary (BNF)

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Conceptually, Rya can encrypt the intended query, send it to one or various hospitals, and then let the hospitals transform the encrypted query into an encrypted DP-protected reply, which Rya can later decrypt (see Figure 6)

To bridge the gap between bench and bedside, rigorous examinations of human models must be conducted to gauge the pharmacokinetic, efficacy, and long-term safety profile of the systems