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In addition, the combination of therapies to mitigate long-term complications, such as drug resistance, is essential to improve treatment efficacy

Overuse or misuse may lead to side effects like: Gastrointestinal discomfort Allergic reactions (in rare cases) Interaction with other medications Note: Long-term use, especially IV glutathione, should always be guided by a trained aesthetic physician

Hence, we propose that the maintenance of high, nearly-constant, GSH levels in R cells, compared to S cells, along with high increasing taurine levels (whereas taurine remains lower and constant in S cells), may indicate that the antioxidative mechanisms in R cells rely preferably on the hypotaurine/taurine pair, rather than on GSH/GSSG

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