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On the other hand, inducers increase P-450 activity by increasing enzyme production, or, in the case of CYP2E1, preventing degradation in the proteasome

Accordingly, pharmacological inhibition of SLC7A11 or cysteine deprivation blocks GSH synthesis, leads to GSH depletion, and induces ferroptosis by disabling the antioxidant defense system 85,137

This review synthesizes recent advances in understanding the ironenergy metabolism axis in AD, delineates mechanisms by which iron imbalance precipitates mitochondrial dysfunction and glucose metabolic impairments, and evaluates how these deficits synergize with neuroinflammation and proteinopathy across disease stages