chac1 er stress glutathione degradation (GSH) depletion by results in a more oxidizing ChaC1-based drug screenings identify a

ChaC1 based drug screenings identify a synergistic lethal effect of auranofin and proteasome inhibitors in hepatocellular carcinoma cells Cell Death Discovery Frontiers CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF CRE Regulatory Element* Journal of Biological Chemistry Dysregulated lipids homeostasis disrupts CHAC1 mediated ferroptosis driving fibroblast growth factor receptor tyrosine kinase inhibitor AZD4547 resistance in gastric cancer ScienceDirect

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