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At a psychological level, a lack of vitamin B12 can lead to listlessness, depressive mood, difficulty concentrating, nervousness, and sleep disorders

Vitamin B12 injections are said to be effective at increasing blood levels of B12, preventing or reversing deficiency of the same

Daratumumab triggers CD38 + multiple myeloma cells [via antibody-dependent cellular cytotoxicity (ADCC), complement dependent cytotoxicity (CDC), and tumor-associated macrophages (TAMs)] in sensitive and drug-resistant patients, regulates the enzyme activity of CD38, reduces the level of adenosine and reduces adenosine-induced immunosuppression

The identification of the underlying sleep disorder drives the specific therapeutic approach, which is based on PD-specific measures and also refers to guidelines for other stand-alone disease entities such as RLS, insomnia or SDB