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This cytosolic pseudo-starvation signal, caused by the sequestration of iron within the mitochondrial matrix and the concomitant failure of ISC biogenesis, triggers a compensatory but ultimately maladaptive response [2,99,100]

Another section is dedicated to radiation-induced graft polymerization as a subtopic this review

During the development of osteoarthritis, the synovium undergoes interstitial vascularization, fibrosis and hyperplasia (167), and macrophages and fibroblasts in the synovium can release proinflammatory cytokines, etc., which cause synovitis and cartilage degeneration