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On the other hand, activation of the bile acid nuclear receptor farnesoid X receptor (FXR) changes the structure of the gut microbiota, thus affecting the metabolism of bile acid and inducing the activation of intestinal grain filling rate 5 to increase the secretion of glucagon-like peptide-1 in intestinal endocrine L-cells to control glucose homoeostasis and improve liver insulin sensitivity and liver metabolism

Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis

These mutations result in decreased expression of SMN protein, which functions chiefly as part of a complex (the SMN complex) that plays a crucial role in eukaryotic mRNA processing [9][11]