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Examples of DAMPs include high-mobility group box 1 (HMGB1) and heat shock proteins (HSPs), which, together with other pro-inflammatory mediators, contribute to the disruption of the bloodbrain barrier (BBB) (19)

Although HNPs have direct and potent antimicrobial activities, 185 these peptides also control infection during acute infection by modulating various immune activities such as chemotaxis, phagocytosis, and cytokine induction