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Nonetheless, there is still some room for improvement, namely developing a strategy with a variable rpm (scheduled or even adaptive), so that it can be adjusted according to process requirements

Its physiological concentration declines with age (from ~200 ng/mL at age 20 to ~80 ng/mL at age 60)

Nitrosative stress-induced S-glutathionylation of protein disulfide isomerase leads to activation of the unfolded protein response

Beyond its pathogenic influence, mtDNA also plays a role in shaping the course of pancreatitis through mechanisms that regulate cell survival, such as balancing apoptosis and necrosis, which are pivotal in determining the severity of the disease (115)