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Polyphenols frequently exhibit limited absorption rates and undergo rapid metabolism within the human body, hence constraining their capacity to reach and exert their effects on specific regions within the brain ( in vitro and animal models to clinical practice has been difficult due to the lack of replication of identified effects in human studies

Recovery and reconstruction of energy production and maintaining the energy balance by applying exogenous ALC as an energy source to compensate for the reduced energy in the brain of the mouse model of MS could be addressed as a therapeutic strategy

doi: 10.1007/s13238-014-0077-5 146 XuX.XiaC.HuangY

Metabolic profiles were examined in rat plasma during the following phases: after 16 days of MA self-administration (Group M)