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The multiple functions of tear fluids include: lubrication of the eyelids, formation of a smooth and even layer over the cornea and conjunctiva, providing antibacterial systems for the ocular surface and nutrients for the epithelium, act as a vehicle for the entry of polymorphonuclear leukocytes in case of injury, and washing away the toxic irritants (Lemp and Blackman 1981

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Studies have shown that HO-1 may be involved in the development of diabetic complications like diabetic kidney, diabetic cardiovascular disease, and diabetic wound healing

[101] Film critic Paul Clinton of CNN thought the film was fairly compelling, saying of Reeves's acting: "[Raimi] managed to get a performance out of Reeves that only occasionally sounds like he's reading his lines from the back of a cereal box." [102] In 2001, Reeves continued to explore and accept roles in a diverse range of genres