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In particular, variations in the transcripts for the ThDP-dependent enzymes with relatively high enterocytic expression, i.e., OGDH, HACL1 and PDHA1, are coupled with those in the transcripts for ALPI and ThDP transporter SLC44A4, all belonging to the cluster 2b including the three proteins with decreased transcripts 1 month after the bypass (Figure 5A in bold)

While there are established pharmacological guidelines for the prevention of migraines (2, 3), a significant number of patients still experience unmet needs, with many not benefiting from or failing to respond to preventative treatments (4, 5)

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