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(PubMed) How TB-500 Works TB-500 is not full-length TB4 its the N-acetylated 1723 fragment (Ac-LKKTETQ) that corresponds to TB4s actin-binding region

11,39,40 As deeper and more robust sequencing technologies emerge, studying genetic differences at a single-cell level will likely reveal even further complexities in the patterns of metastatic spread

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The peptide disrupted FOXO4-p53 co-localization at PML nuclear bodies, releasing p53 to translocate to the mitochondria and trigger the intrinsic apoptosis pathway (Baar et al., 2017)