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For the majority, these symptoms are mild, but as many as 25% of women report that these symptoms are moderate to severe

Regeneration of tubular epithelial cells promotes recovery, whereas interstitial fibrosis and loss of renal capillaries are associated with progression to CKD (150)

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Mitochondrial gene function was perturbed using a custom arrayed shRNA library targeting 1,087 genes (median 5 hairpins/gene), most of which (901, 88%) encode predicted mitochondrial proteins (Pagliarini et al., 2008) (FIG