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Simultaneously, astrocyte-related lipid metabolism disorders induce lipotoxicity in neurons and hinder the normal physiological function of neurons

EMBO J (2005) 24(13):233141

Lai et al., 2019

Interestingly however, clinical data has shown that lower ACC1 expression is associated with poor survival rates, which may suggest that there is a context-dependent tumor suppressor role for this enzyme in certain populations (68)