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Accumulating evidence has shown that MSC-based tissue engineering and regenerative therapy holds great promise to promote nerve regeneration because of the potent immunomodulatory/anti-inflammatory functions and multifaced trophic effects of MSCs, such as neurotrophic or neuroprotective, pro-angiogenic, antioxidant, and anti-fibrotic effects due to their paracrine secretion of a myriad of biological factors [13, 14]

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