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doi: 10.1016/j.jss.2017.04.008 193 VallantNWolfhagenNSandhuBHamaouiKCookTPuseyCet al

However, the CAHS proteins offered a unique advantage in that they could be engineered to optimize protection, making them more flexible and reliable under a range of conditions

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A review study proposed another mechanisms underlying the potential interaction of the smoking and oestrogen metabolites such as decrease in oestrogen activity, SHBG levels, aromatase enzyme activity, C-20, 22 desmolase enzyme levels and increase in free testosterone levels, hyperandrogenism and the hepatic metabolism of steroid (Reference Ruan and Mueck41)