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These NPs significantly enhanced the cytotoxic impact on HCT116 CRC cellsdemonstrating eightfold higher effectiveness compared to free sorafenib

Nevertheless, despite these advances, effective clinical translation remains elusive, and no therapies specifically targeting ferroptosis have yet been approved for cardiovascular indications

Together with HSP70 and HSP90, sHSPs form an integrated chaperone network that buffers neurons against proteotoxic stress, delays aggregate formation, and promotes clearance of damaged proteins