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Additionally, integrating biomarkerguided patient stratification (e.g., based on mitochondrial function or NTFs receptor status) into trial design may help identify subgroups most likely to benefit from axistargeted therapies

CRISPR/Cas9 library screening for drug target discovery

and in older individuals, hypothyroidism accelerates cognitive decline while hyperthyroidism increases anxiety and sleep disturbances ( The thyroidbrain axis represents a complex system of bidirectional communication between endocrine and neural networks