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10.1016/j.bbrc.2016.08.124 Biochem

Furthermore, the anti-inflammatory effects of silybin may synergize with the activation of antioxidant pathways such as nuclear factor erythroid 2-related factor 2 (Nrf2) ( 5.2 The protective mechanisms in hypertension, myocardial infarction, and ischemia-reperfusion injury The occurrence and development of hypertension are closely related to vascular inflammation and vascular remodeling

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Track dosing in a clear plan: starting dose, escalation steps, monitoring frequency, and stop rules for adverse events