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Alternatively, DSPE-PEG-GSH is added after preparation of the liposomes by incubation at 25 0 C up to 6O 0 C for 2 up to 24 hours (depending on the transition temperature of the lipid mixture and the temperature sensitivity of the agent)

To maintain vitamin B12 status, the alternatives to high oral doses of cobalamin (500-1000 micrograms daily) are routine intramuscular doses at one mg per month