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Primary & Secondary Bile Acids: Thyroid hormones help to regulate the rate of bile acid synthesis as well as flow of bile acids from liver, into gallbladder, and into the intestinal tract Secondary bile acids, initially triggered by thyroid hormones, impact energy metabolism by influencing insulin sensitivity and thus blood sugar regulation as well as activating D2 (the T4 to T3 enzyme)

Interestingly, recent research in human and rodent granulosa cells has shown that intact IGF-1R signaling was also required for FSHR-mediated phosphorylation of Akt (66, 113)

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