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Furthermore, the combined use of CBL0137 and panobinostat markedly prolonged the viability of mice transplanted with diffuse intrinsic pontine glioma (DIPG) cells, offering a promising treatment strategy for DIPG 151

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217,218 It supports high biosynthetic and energetic demands of rapidly proliferating cells and may facilitate dormancy of residual tumor cells following chemotherapy or radiation, contributing to recurrence and metastasis