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As metabolic ROS is causally linked to mutant KRAS-induced tumorigenicity and requires homeostatic mechanisms to maintain ROS levels within a threshold favorable for tumor development (14,27-30,41), the identification of LDHB and SLC7A11/GSH/GPX4 converging on a role as ROS scavengers reveals an unanticipated metabolic vulnerability in KRAS -mutant cancers