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Mice with HIF-1 deficient T cells are resistant to induction of T H 17-dependent experimental autoimmune encephalitis associated with diminished T H 17 and increased Treg cells

Complications may be lethal

Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P, Damico D, Ropelle ER, Lutolf MP, Aebersold R (2016) NAD + repletion improves mitochondrial and stem cell function and enhances life span in mice