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it is a severe adverse effect that can limit dose and choice of chemotherapy Many substances already approved for treating neuropathic pain failed to ameliorate CIPNP in clinical trials, underlining the importance of assessing drug efficacy in CIPNP independently of other neuropathic pain states CIPNP has distinctive mechanisms that depend on the causative cytostatic drug

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As such, further research is necessary ( Summary Research suggests that some probiotic strains, including Bifidobacterium lactis, may help improve symptoms of constipation