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MPO reacts to form highly toxic products such as hypochlorous acid and tyrosyl radicals which deteriorate the normal tissues leading to oxidative stress and inflammation (Hansberry et al., 2017)

Specifically, intra-articular injection or systemic administration of specific ferroptosis inhibitors such as ferrostatin-1, or pharmacologically for example, using natural products or genetically for example, using overexpression vectors upregulating GPX4 expression, activating SLC7A11, or the key transcription factor Nrf2, can, to varying degrees, restore cartilage morphology, reduce chondrocyte death, and significantly lower the expression levels of ECM degradation markers in OA animal models

Designation categories have been established and sunsetted over the years in response to global health events

Huang Q, Ding Y, Fang C, Wang H, Kong L