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Again, glutathione peroxidase 1 (GPx-1) is a critical enzyme in the protection of vessels against atherogenesis

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It also improves endothelial function by lowering ET-1 and thromboxane B2 levels while increasing CGRP levels, inhibits apoptosis by modulating B-Cell Lymphoma-2 (Bcl-2), Bcl-2-associated X protein (Bax), and caspase-3 expression, and suppresses NOD-like receptor protein 3 (NLRP3) inflammasome activation via the toll-like receptor 4 (TLR4)/NF-B signaling pathway (Guo et al., 2015)