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This could theoretically alter the peak plasma concentration (Cmax) and time to peak concentration (Tmax) of co-administered oral drugs

Patients undergoing HSCT may have IO due to blood transfusion.[] The pretransplant iron status can be assessed by measuring ferritin levels because ferritin still does not increase as an acute-phase reactant or is not affected by liver toxicity secondary to chemo-radiotherapy.[] Furthermore, the transferrin saturation index (TSI) increases during chemotherapy, generally reaching more than 80%, and nontransferrin-bound iron is produced.[] TSI may provide information about the potential toxic effect of free iron that occurs during the preparation regimen

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