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4.2.2.2 Metabolic significance of phenylacetylglutamine Phenylacetylglutamine (PAGln) is a gut microbiota-dependent metabolite that has attracted considerable attention in recent years, formed from dietary phenylalanine metabolized by gut microbiota to phenylacetic acid and subsequently conjugated with glutamine in the liver (126)

In two of the OPM-2 xenografts, BSO+L-PAM reduced tumor volumes of 1330 mm 3 and 972 mm 3 to 2), inducing CRs in majority of the mice treated (21/25), achieving MCRs in 6/25 mice, and doubling the median EFS relative to L-PAM alone ( P 80% was not cytotoxic, whereas three cell lines were affected by BSO

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The formula typically includes methionine, inositol, and choline (MIC), combined with vitamin B12 to help the body efficiently process fats and support natural detox pathways